Alpha Lipoic Acid: Does it Work?

Since humans can only produce ALA in small amounts, many people turn to supplements to increase their intake. Some claim that ALA may help people lose weight. For example, one study on an animal model found that ALA could improve skeletal muscle energy metabolism, possibly increasing how many calories the body can burn. However, studies also show that the impact of ALA on weight loss is small. According to a analysis , those taking ALA supplements only lost an average of 1.

Some research suggests that ALA may help the body control blood sugar levels and improve cholesterol levels. Research has also shown that it could reduce nerve damage symptoms that are common in people with diabetes, such as numbness, pain, and paralysis. CRP is an inflammation marker that may indicate chronic inflammation linked to harmful diseases such as diabetes and cancer.

According to some research , ALA, because it is a potent antioxidant , may help reduce oxidative stress.

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Oxidative stress is one of the primary causes of heart disease. A review of several randomized controlled trials also found that ALA could lower levels of "bad" cholesterol, another risk factor for heart disease. Oxidative stress occurs naturally with age.

What is ALA?

As well as playing a role in the development of heart disease, it also plays a critical role in brain health and memory loss. According to a study in participants with Alzheimer's disease , ALA may slow the progression of the condition.

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The researchers suggested that this might be due to ALA's positive effects on insulin resistance and blood sugar metabolism, as diabetes is a risk factor for Alzheimer's disease. Some studies show that ALA may have health benefits including reducing inflammation, aiding weight loss, and lowering the risk of heart disease. However, many of these studies were small, short-term, or in animal models.

More research is needed to determine whether ALA is an effective treatment or preventative measure for the conditions and issues listed above. Doctors consider ALA to be safe for most people, with little to no risk of side effects.

Alpha-Lipoic Acid

Mild effects may include nausea, rashes, and itching if a person takes high doses. According to researchers , adults may take it up to 2, milligrams without serious side effects. There is not enough research and evidence on the extra benefits and potential side effects of taking higher doses, so medical professionals do not recommend it. There is not enough evidence on its safety for use in children, however, so adults should always keep ALA in a safe place. It is essential for people considering taking ALA supplements to talk to their doctor to see if it is right for them. ALA is an organic compound that acts as an antioxidant and has a variety of other effects on the body.

While the body makes it naturally, some people also choose to take ALA supplements. Research suggests that ALA may help with weight loss, diabetes, memory loss, and some other health conditions. However, there is not enough research to understand its full benefits or effectiveness in humans. ALA is generally safe for adults, but it is best to speak with a doctor before taking any new supplements. ALA supplements are available in some pharmacies, health food stores, and online.

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Alpha-Lipoic Acid - Side Effects, Dosage, Interactions - Drugs - Everyday Health

We partner with some of the companies that sell these products, which means Healthline UK and our partners may receive a portion of revenues if you make a purchase using a link s above. Article last reviewed by Mon 19 November All references are available in the References tab. The effects of alpha-lipoic acid supplementation on glucose control and lipid profiles among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials [Abstract].

The effect of lipoic acid therapy on cognitive functioning in patients with Alzheimer's disease. Journal of Neurodegenerative Diseases , Diabetes and alpha lipoic acid. Lipoic acid — biological activity and therapeutic potential. Alpha lipoic acid intoxication, treatment and outcome. Clinical Toxicology , 51 6 , Alpha-lipoic acid supplement in obesity treatment: A systematic review and meta-analysis of clinical trials [Abstract].



Energy metabolism and redox regulation of transcription and cell signaling. The protective effect of lipoic acid on selected cardiovascular diseases caused by age-related oxidative stress. Oxidative Medicine and Cellular Longevity , Everything you need to know. In a human study, scientists found that applying a cream containing alpha-lipoic acid to the skin reduced fine lines, wrinkles and skin roughness with no side effects Moreover, alpha-lipoic acid raises the levels of other antioxidants, such as vitamin C and glutathione , which help protect against skin damage and may reduce signs of aging 21 , Memory loss is a common concern among older adults.

Because alpha-lipoic acid is a powerful antioxidant, studies have examined its ability to slow the progression of disorders characterized by memory loss, such as Alzheimer's disease. However, there are only a handful of studies on alpha-lipoic acid and memory loss-related disorders. More research is needed before alpha-lipoic acid can be recommended for treatment. Moreover, taking alpha-lipoic acid before and after surgery for carpal tunnel syndrome has been shown to improve recovery outcomes Studies have also discovered that alpha-lipoic acid may ease symptoms of diabetic neuropathy, which is nerve pain caused by poorly controlled diabetes 14 , In an analysis of 11 studies, alpha-lipoic acid significantly lowered levels of the inflammatory marker C-reactive protein CRP in adults with high levels of CRP Heart disease is responsible for 1 in 4 deaths in America Research from a combination of lab, animal and human studies has shown that the antioxidant properties of alpha-lipoic acid may lower several heart disease risk factors.

First, antioxidant properties allow alpha-lipoic acid to neutralize free radicals and reduce oxidative stress, which is linked to damage that can increase heart disease risk In some cases, people may experience mild symptoms like nausea , rashes or itching.

However, research shows that adults can take up to 2, mg without harmful side effects Not to mention, animal research has found that extremely high doses of alpha-lipoic acid may promote oxidation, alter liver enzymes and place a strain on liver and breast tissue 38 , To date, there are very few studies that look at the safety of alpha-lipoic acid in children and pregnant women. People who fall into these categories should not take it unless advised by their doctor.

If you have diabetes, ask your doctor before taking alpha-lipoic acid, as it may interact with other medicines that help lower blood sugar levels. Good sources of alpha-lipoic acid include Alpha-lipoic acid is also available as a supplement and can be found in many health stores.

Supplements can contain up to 1, times more alpha-lipoic acid than foods 3. Though there is no set dosage, most evidence suggests that — mg is sufficient and safe. Alternatively, you can follow the instructions on the back of the bottle. People with diabetic complications or cognitive disorders may require more alpha-lipoic acid.

Alpha-lipoic acid is an organic compound with antioxidant properties. It's made in small amounts by your body but also found in foods and as a supplement. Antioxidants help defend your cells from damage. These 12 foods are high in antioxidants and can help keep your cells healthy.

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