Inherent Stability Collection

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Inherent stability of helicopters , report , October ; digital. One of 1, reports in the series: Showing of 12 pages in this report.

Aeroplane design a single explanation of inherent stability

Description The equilibrium, in still air, of a "stationary" helicopter i. Who People and organizations associated with either the creation of this report or its content. National Advisory Committee for Aeronautics. About Browse this Partner. What Descriptive information to help identify this report.

Inherent stability of helicopters Series Title: Subjects Keywords aircraft stability helicopters. Identifier Unique identifying numbers for this report in the Digital Library or other systems. Accession or Local Control No: Collections This report is part of the following collections of related materials. A Chromatogram of sunlight treated direct sunlight for 8 day pramipexole sample. The LC—MS analysis of photodegraded sample showed major degradation product at 6.

Possible degradation product formed under photochemical degradation was confirmed as 4,5,6,7-tetrahydro propylamino benzothiazolyl carbamic acid Fig. Pramipexole was found to be stable as negligible degradation was seen when subjected to dry and wet heat. The results of validation studies on the stability-indicating method developed for pramipexole involving methanol: The drug response was linear 0.

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The results of the repeatability and intermediate precision experiments are indexed in Table 1. One factor at a time was changed to determine the effect. Insignificant differences in peak areas and less variability in retention time were observed Table 2. The resolution of drug in the mixture of stressed sample was found to be similar when studies were performed on different chromatographic systems on different days, indicating that the method has sufficient ruggedness.

The peaks obtained were sharp and had clear baseline separation. Commercially available pramipexole tablets from two different lots were analyzed using the proposed procedures and the results are indexed in Table 3. As can be seen in Table 4 good recoveries of the drug in the range from An analytical method for determination of pramipexole in the presence of degradation products was developed. Using various ICH recommended stress conditions, the behavior and intrinsic stability of pramipexole under various stress conditions was established and all degradation products were identified by the LC—MS method.

The drug was well separated from the degradation products demonstrating the stability indicating capability of the method. This study could be very useful for checking the quality of drug during stability studies. We would like to thank Dr. Hyderabad, Andhra Pradesh, India for providing gift sample of standard pramipexole.

The authors would also like to thank Dr. Peer review under responsibility of Xi'an Jiaotong University. National Center for Biotechnology Information , U. Journal List J Pharm Anal v.

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Published online Aug Pawar , a Laxman D. Khatal , b Satish Y.

Gabhe , a and Sunil R. Author information Article notes Copyright and License information Disclaimer. Received Apr 28; Accepted Jul Abstract Pramipexole belongs to a class of nonergot dopamine agonist recently approved for the treatment of early and advanced Parkinson's disease.

Introduction Pramipexole is a new drug used in the therapy of Parkinson's disease. Open in a separate window. Materials and chemicals A pure drug sample of pramipexole Batch no.

Instrumentation The LC method development, forced degradation studies and validation were done using Jasco Inc. Validation of the method Validation of the optimized LC method was done with respect to following parameters. Precision Precision was computed here by repeatability and intermediate precision.

Robustness of the method To evaluate robustness of the HPLC method, few parameters like variation of flow rate and percentage of methanol in the mobile phase were deliberately varied. Specificity The specificity of the method was established through study of resolution factor of the drug peak from the nearest resolving peak.

Analysis of marketed formulation To determine the pramipexole content in conventional tablets Brand name: Results and discussion 3. Results of forced degradation studies 3. Hydrolysis The rate of degradation in base was faster as compared to acid. A hydrolysis, B oxidation and C photolysis. Dry and wet heat degradation Pramipexole was found to be stable as negligible degradation was seen when subjected to dry and wet heat. Results of method validation The results of validation studies on the stability-indicating method developed for pramipexole involving methanol: Linearity The drug response was linear 0.

Precision The results of the repeatability and intermediate precision experiments are indexed in Table 1. Table 1 Precision studies for pramipexole. Analysis of marketed formulation Commercially available pramipexole tablets from two different lots were analyzed using the proposed procedures and the results are indexed in Table 3. Recovery studies As can be seen in Table 4 good recoveries of the drug in the range from Conclusion An analytical method for determination of pramipexole in the presence of degradation products was developed.

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Acknowledgements We would like to thank Dr. Footnotes Peer review under responsibility of Xi'an Jiaotong University. Martindale-The Complete Drug Reference. Effectiveness of pramipexole, a dopamine agonist, on rapid eye movement sleep behavior disorder. Determination of pramipexole u, in human plasma by high-performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry. Experimental design in chromatographic analysis of pramipexole and its impurities.

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LC method for the determination of pramipexole using an experimental design. Validated chiral liquid chromatographic method for the enantiomeric separation of pramipexole dihydrochloride monohydrate.