COX-2 Blockade in Cancer Prevention and Therapy (Cancer Drug Discovery and Development)
Section IV then discusses the molecular biology of COX -2 vis-a-vis the role of COX -2 and, to a lesser extent, COX -1, in modulating a number of important processes in molecular carcinogenesis such as mutagen esis, cell division, angiogenesis, cell differentiation, and apoptosis. The authors elucidate the process by which COX-2 inhibitors interrupt prostaglandin biosynthesis and cancer development, examine the positive epidemiological effects of such NSAIDs as aspirin and ibuprofen on various cancers, and demonstrate through animal models that COX-2 inhibitors and NSAIDs inhibit a variety of malignant neoplasms in vivo.
- The Barn at Brook Farm Part Two.
- Cyclooxygenase-2 and Cancer Treatment: Understanding the Risk Should Be Worth the Reward.
- COX-2 Blockade in Cancer Prevention and Therapy!
- Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention;
- Short Science Fiction Stories For When Youre Bored.
In addition, the authors review the clinical applications of selected NSAIDs that are immediately relevant to cancer prevention and control and outline the future prospects of COX-2 blocking agents. This text documents the converging evidence that COX-2 blocking agents and other non-steroidal anti-flammatory drugs NSAIDS have chemopreventure and therapeutic effects against virtually all forms of cancer.
It also covers the epidemiologic evidence suggesting that COX-2 inhibitors protect against cancers of the colon, breast and other anatomic sites; animal and molecular models demonstrating that these compounds block critical steps in carcinogenesis; and pharmacologic findings and clinical applications which are immediately relevant to cancer prevention, therapy and control. Additional Details Number of Volumes.
Table Of Content Part I. Reddy and Chinthalapally V.
New NSAID Targets and Derivatives for Colorectal Cancer Chemoprevention
Alshafie, and Randall E. Gupta and Raymond N.
Harmon, and Jaime L. Richards and Robert W. Hsi and Thomas E. Steele, and Caroline C. Anderson, Asad Umar, Jaye L. Viner, and Ernest T. Widening the Scope of ImpactRandall E. Harry Potter Years by J.
Lipoxygenase and Cyclooxygenase Pathways and Colorectal Cancer Prevention
Rowling , Hardcover Harry Potter and the Sorcerer's Stone 1 by J. Harry Potter Boxset Books by J.
Language English View all editions Prev Next edition 3 of 3. Series Cancer drug discovery and development Subjects Cancer -- Chemoprevention. Cyclooxygenase 2 -- Inhibitors -- Therapeutic use.
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Contents Machine derived contents note: Reddy and Chinthalapally V. Alshafie, and Randall E. Gupta and Raymond N. Harmon, and Jaime L. Richards and Robert W. Hsi and Thomas E.
COX-2 Blockade in Cancer Prevention and Therapy : Randall E. Harris :
Steele, and Caroline C. Anderson, Asad Umar, Jaye L. Viner, and Ernest T. Widening the Scope of Impact 3 Index 3. Notes Includes bibliographical references and index. View online Borrow Buy Freely available Show 0 more links