ARVO 2010 Abstracts - Genetics Group

This feature is available to authenticated users only. Three dimensions of quantitative metamorphopsia measurement — do disease specific patterns exist? Longitudinal analysis of structural and functional changes in patients with reticular drusen and age-related macular degeneration Open Access. Changes in the foveal avascular zone in maculopathy patients with intravitreal anti-VEGF injection observed by optical coherence tomography angiography Open Access. Early changes in retinal morphology during the first three weeks after anti-VEGF re- treatment for neovascular age-related macular degeneration Open Access.

Comparison of the reliability of confocal color, flash color, and fundus autofluorescence imaging for the quantitative assessment of geographic atrophy Open Access.

Morphologic risk factors for disease progression in early and intermediate age-related macular degeneration Open Access. Inter-scan repeatability of drusen and geographic atrophy measurements using spectral domain optical coherence tomography in eyes with Age related macular degeneration Open Access. Fundus autofluorescence and choroidal thickness by spectral domain optical coherence tomography in dry age-related macular degeneration in mexican population Open Access.

Lesion area, perimeter and diameter as prognostic markers for the progression of geographic atrophy GA secondary to age-related macular degeneration Open Access. Expeditious bilateral murine fundus fluorescein angiography FFA: Maximizing optical imagery with a transportable digital camera Open Access.

Retinal pseudocysts in geographic atrophy secondary to non-exudative age-related macular degeneration Open Access.

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Difference between polypoidal choroidal vasculopathy and age-related macular degeneration in spectral domain OCT: Optical coherence tomography angiography in treated neovascular age related macular degeneration Open Access. Fundus autofluorescence from drusen is spectrally different from that of lipofuscin Open Access. Optical coherence tomography features preceding the onset of geographic atrophy and neovascular disease Open Access.

Assessing lesion activity in neovascular AMD from colour images and optical coherence tomograms Open Access. Ivana N Despotovic; Eric M. Ploner; Jennifer Zacharia; A. Retinopathy correlation to frequency and severity of blood glucose spikes in Type 1 Diabetes using continuous glucose monitors Open Access. A Retrospective Analysis Open Access. Comparison of quantitative versus subjective assessment of lesion distribution in diabetic retinopathy Open Access.

Anti-inflammatory effects and mechanisms of metformin on high-glucose challenged monocytes Open Access. Joanne Tayapad Rocha; April N. Aflibercept for treatment-resistant DME: The influence of intraocular pressure on the severity of diabetic retinopathy Open Access. Successful panretinal photocoagulation leads to changes in the retinal venular vascular geometry in patients with proliferative diabetic retinopathy.

Self-help, lifestyle and awareness influence sight-threatening retinopathy in patients attending diabetic eye clinics in India and Nepal Open Access. Early retinal changes in Optical Coherence Tomography in patients with type 1 diabetes under intensified insulin therapy Open Access.

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Real-life visual and anatomical outcomes with fluocinolone acetonide FAc and cumulative cost of treatment in the treatment of chronic diabetic macular edema DME Open Access. Retinal oxygen saturation is an independent contributor to the severity of retinopathy in diabetic patients Open Access. Parafoveal OCT angiography features in diabetic patients without clinical diabetic retinopathy: Patient comfort using green nm versus yellow nm panretinal photocoagulation with the laser indirect ophthalmoscope for proliferative diabetic retinopathy Open Access.

The need for early retinopathy screening and improved awareness in diabetic patients in Hangzhou, China. The region-dependent neovascularization and macular layer-specific edema and ischemia in proliferative diabetic retinopathy Open Access. Correlation of total HbA1c load with prevalence of diabetic retinopathy among type 1 diabetic patients treated with intensified insulin therapy from the onset of disease Open Access.

ARVO Visionary Genomics

Ploner; Carl B Rebhun; A. Efficacy and safety of Fluocinolone acetonide implant use for the treatment of refractory diabetic macular oedema and its impact on the hospital diabetic eye services Open Access. Comparison of efficacy of intravitreal versus sub-Tenon injection of triamcinolone acetonide during cataract surgery for diabetic macular edema Open Access. Thioredoxin plays a key role in retinal neuropathy prior to endothelial damage in diabetic mice Open Access.

One-year safety outcomes of intravitreal implant of fluocinolone acetonide 0. Reduced foveal thickness correlates with depressed foveal visual function in eyes with diabetic retinopathy Open Access. Quantification of retinal nonperfusion associated with neovascularization in diabetic retinopathy using ultrawide field fluorescein angiography Open Access. Opening the Black Box: Huang; Caroline Yu; Robert A. Evaluation and referral of diabetic eye disease within the endocrinology and primary care office setting: A quality improvement project Open Access.

Cecilia Lansang; Rishi P Singh. Advanced Glycation Endproducts in capsulorhexis specimen: Correlation with Diabetic Retinopathy. Variability of retinal layer thicknesses within diabetic subjects Open Access. Switching corticosteroids therapy for diabetic macular edema Open Access. Outer retinal changes in patients with diabetes and no or mild non-proliferative diabetic retinopathy Open Access. Sustained release intravitreal dexamethazone implant in the treatment of proliferative diabetic retinopathy and diabetic macular edema Open Access. Severe retinal dysplasia and detachment in mice lacking Maturin Open Access.

Immature photoreceptor layer and inner retinal layers in full term neonates identified with optical coherence tomography Open Access. The effect of rhythmic activity on neurite outgrowth of developing retinal explants in rd1 mice Open Access. Elucidating the roles of homeodomain transcription factors Six3 and Six6 in retinal differentiation Open Access.

Characterization of zebrafish her9 regulation and function in retinal development Open Access. Temporal and spatial inhibition of Mab21L2 as a model system for coloboma and anophhtalmia Open Access. Loss of Macf1 abolishes ciliogenesis and disrupts apicobasal polarity establishment in the retina Open Access. Characterization of Capn5 expression and function in the zebrafish retina Open Access.

Identification and characterization of long noncoding RNAs in retinal progenitor cell competence Open Access. Age-dependent post-translational modification of neuronal activity-regulated pentraxin Narp in the mouse retina Open Access. Ushananthini Shanmugalingam; Abigail E. Dopamine is an Opsin 5-dependent modulator of vascular development in the eye Open Access.

Identification of an enhancer that regulates Otx2 expression during early retinal differentiation Open Access.

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Cell cycle gene reactivation in rd1 mouse retina prior to degeneration Open Access. Retinoic acid engineered amniotic membrane used as a graft or homogenates: Sphingolipids in the Human Cornea, to boldly go where no one has gone before Open Access. Novel approaches to anchoring therapeutic factors to corneal stroma to promote wound healing.

Evaluating the effect of hyaluronic acid-containing artificial tear products on corneal wound re-epithelialization in an in vivo preclinical study. Effect of ST, an amnion-derived multipotent progenitor cell-derived secretome, in a corneal incision model for post-operative inflammation Open Access. Alginate-encapsulated adipose-derived stem cells: Semaphorin3A is an inducer of neuronal growth and nerve regeneration in adult corneas. Transparency of suture able, nanofiber reinforced, alginate hydrogels for corneal wound healing Open Access.

Expression in the cornea and its role in corneal wound healing Open Access. The effect of human growth hormone on corneal wound healing in mice Open Access. Growth of human corneal epithelial cell on silk films with different nanotopographies. Optimized gene therapy normalizes wound healing and stem cell marker expression in cultured diabetic limbal epithelial cells. Effect of conditioned medium on corneal epithelial cells wound healing in vitro Open Access.

Influence of the molecular weight on the suture retention properties of polycaprolactone Open Access. Mice gender and strain affect neurotrophin secretion and corneal nerve regeneration after injury Open Access. Potential role of topical bovine colostrum in remodeling corneal epithelial cells after an acute ocular alkali burn in mice Open Access. Corneal Keratocytes Open Access. Corneal wound healing mechanisms modulated by novel antimicrobial peptides Open Access. Anne Kasus-Jacobi; Amanda J.

Effects of exogenous recombinant human bone morphogenic protein-7 on the corneal wound healing Open Access. An ex vivo model using porcine eyeballs for wound healing studies Open Access. Corneal woundhealing model employing a bioreactor Open Access. Outcomes of multiple-dose fibrin glue during in-office pterygiectomy Open Access. Gregory A Hutcheson; David O. Interleukin-6 expression in an ex vivo model of equine corneal wound healing Open Access. Thermal injuries of the cornea: Injury patterns and histopathology Open Access.

Genetic, environmental and phenotypic risk factors for progression of age-related macular degeneration Open Access. Getting to the root of MacTel: Incidence and de-novo mutation rate of Marfan syndrome and risk of ectopia lentis Open Access. Heritability of retinal vascular fractals: Newly identified genes for refractive error and risk of myopia Open Access. European ancestry is associated with lower risk of primary open angle glaucoma in Latinos Open Access. Genetic heritability and associations of Pigmentary Glaucoma Open Access.

The Amish Eye Study: Systemic Effects of AAV. H suppresses neovascularization through inhibition of secretion of VEGF and proliferation of vascular endothelial cells Open Access. The efficacy of aflibercept in treating retinopathy of prematurity in the mouse model of oxygen-induced retinopathy Open Access. Clay Smith; Jade Gieseke Guevara. Blockade of Apelin Receptor APJ can inhibit developmental retinal vessel outgrowth in pups and promote normal revascularization and reduce pathological neovascularization in OIR model i Therapeutic potential of topical administration of H, an isoquinoline sulfonamide derivative, in wet AMD and proliferative diabetic retinopathy Open Access.

The long leap from drug affinity to efficacy: Intervening factors that strongly influence clinical outcomes Open Access. Panobinostat reduces neovascularization in an alkali-induced corneal injury model Open Access. Anti-VEGF induced nephropathy following intravitreal administration: Effects of anti-angiogenic drugs on expression patterns of genes involved in different AMD pathogenetic pathways Open Access. Tarek Moustafa; Shari R. Ciliary neurotrophic factor in patients with age-related cataract Open Access.

Surface analytical studies of growth factor coupling to collagen by copper-free click chemistry Open Access. An increased expression of IL and Foxp3 is observed in contrast to other Th genes in primary pterygium Open Access. Quantification of aflibercept and ranibizumab efficacy in DLaminoadipic acid DLAAA -induced retinal neovascularization and vascular leakage in nonhuman primates Open Access.

Comparison of pain and comfort for intravitreal administration of anti-VEGF agents using blepharostat vs non blepharostat techniques. Increased levels of nitric oxide may pathologically affect functional hyperemia in the retina: Treatment outcomes of chronic central serous retinopathy in women compared to men Open Access. Microelectrode penetration of the wall of porcine retinal arterioles in vitro results in recordings from at least two different cell types.

Mouse retina is amenable to cholesterol lowering by a statin Open Access. Impaired retinal signal transmission in simvastatin fed mice Open Access. One year retrospective analysis of ocriplasmin for the treatment of symptomatic vitreomacular traction Open Access. Effect of exogenous carotenoids on retinal pigment epithelium cells Open Access. Post-hypoxic recovery of the diameter of retinal arterioles is impaired in diabetic patients without retinopathy. Cost effectiveness of Intravitreal Ocriplasmin for vitreomacular adhesion and macular hole Open Access. Intersectional strategies for targeting amacrine and ganglion cell types in the mouse retina Open Access.

Modulation of electrical activity in the retina of the rd10 mouse model using neuroprotective drugs Open Access. Najafi KK, et al. Romanowski EG, et al. ARVO E-abstract They used a rabbit model of ocular viral infection to show that ALA can significantly reduce the duration and severity of ocular infections. Gordon YJ, et al. ARVO E-abstract While it wasn't as effective as the positive control cidofovir , it displayed little of the toxicity associated with currently available antiviral drugs, including cidofovir.

Researchers reported interim results from a multicenter, open-label trial examining anti-TNF antibody adalimumab Humira, Abbott as a therapy for refractory uveitis. Treatment involved a 40 mg sc injection every two weeks and assessment of safety and efficacy over a week trial. Inclusion in the study required diagnosis of noninfectious uveitis refractory to corticosteroids and at least one immunosuppressive. Endpoints included acuity improvement, de--creased intraocular inflammation and steroid tapering.

Seventeen of 26 patients who completed the week trial responded positively to therapy, and 15 of these continued with treatment for 50 weeks. One initial responder discontinued treatment due to a loss of efficacy, and the only significant adverse event was unrelated to adalimumab. Salom D, et al. Several other trials examined the use of monoclonal antibody mAb therapy targeting other immuno-modulators. Most of these agents were originally developed to treat systemic disorders but they have significant therapeutic potential in ocular inflammatory disease.

An open-label study tested AIN, a humanized monoclonal directed against IL, for patients with noninfectious uveitis. Efficacy variables included acuity, vitreous haze, anterior chamber inflammation and reduction of corticosteroid dosing. Eight of 11 patients 73 percent with posterior segment uveitis and three of five patients 60 percent with anterior uveitis met the response criteria in this study. Only one patient showed no response and required prednisone rescue. Samson CM, et al. ARVO E-abstract Another study examined safety and efficacy of rituximab, an anti-CD mAb developed to treat B-cell lymphomas, for refractory scleritis and non-infective orbital inflammation.

A total of 15 patients received rituximab infusion or 1, mg on days one and 15 of the study; followed by monthly safety monitoring and efficacy assessment at 24 and 48 weeks. The overall outcome was positive: Four patients were able to taper steroid dosing, and only one patient required increased steroids. Vision was stable or improved in 14 patients, and patient and physician global health assessments also improved.

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The only significant safety issue involved seven of the first nine patients treated; they experienced inflammatory exacerbations after infusion that required adjunctive corticosteroids. This didn't occur in the remaining six patients, nor has it occurred in the patients that have been re-infused since then. Another approach to ocular inflammation is the use of lipid-derived agents.

One study reported that the endogenous lipid eicosapentaenoic acid currently in use to treat hyperlipidemias is effective for the treatment of endotoxin-induced uveitis. Suzuki M, et al. Rajasagi NK, et al. Single topical doses reduced intraocular pressure in both rabbits and monkeys. Several in vitro studies provided insights into the underlying mechanism of IOP reduction. In isolated, perfused porcine anterior segments, INO increased trabecular outflow when compared to the vehicle treatment. Kim N, et al.

A recurring theme at both poster and paper sessions was the importance of the Rho-associated, coiled-coil protein kinases referred to by the acronym ROCK.

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These kinases regulate a number of cellular processes including those involved in cytoskeletal and extracellular matrix dynamics. They are attractive therapeutic candidates for modulating the trabecular network and thus improving IOP by increasing outflow. Williams RD , et al. AR showed both time and dose-dependent decreases in IOP, with the largest effect measured two to four hours after the highest dose 0. Whitlock A, et al. Ramachandran C, et al. Building on ocular sign and symptom results reported at last year's ARVO conference, pooled nasal data was presented from two Phase III Conjunctival Allergen Challenge trials using the topical antihistamine bepotastine besilate 1.

The post-hoc analyses show a percent mean reduction of rhinorrhea from baseline at 15 minutes after dosing in the treatment group compared to a 37 percent reduction in the placebo group. Similar results were seen eight hours after dosing, with an average reduction of 81 percent with bepotastine and 27 percent with placebo. These results suggest bepotastine and other drugs of its class may reduce the symptoms of nasal allergies and do so over a prolonged duration.

Gow JA, et al. Besides the standard-of-care topical antihistamines and mast-cell stabilizers, researchers continue to study alternative treatments for ocular allergies including steroids. These results support the use of supratarsal steroid injections in children with allergic conjunctivitis and show that steroid injections may reduce a patient's dependence on topical medications. In an effort to more effectively screen new treatments for allergic conjunctivitis in a preclinical setting, researchers from our group have modified a murine short ragweed SRW sensitization model to enhance the allergic response and reduce the duration of experiments.

The presentations at this year's ARVO meeting were an immense assortment of fascinating research. Pre-ARVO events, poster presentations and special-interest groups prompted stimulating discussion, debate and education. While we're unable to acknowledge all of the research presented at the meeting, we hope we've given you a better understanding of the promising future of eye and vision research, and we look forward to discovering all of the cutting-edge research efforts at future ARVO meetings.

Abelson, an associate clinical professor of ophthalmology at Harvard Medical School and senior clinical scientist at Schepens Eye Research Institute, consults in ophthalmic pharmaceuticals. He thanks the staff at his consulting firm Ora for their contributions to the article. Find a Job Post a Job. ARVO E-Abstract In another Phase I study, the alpha5beta1 integrin antagonist volociximab also exhibited efficacy in the treatment of neovascular AMD when administered intravitreally in combination with ranibizumab.

ARVO E-abstract Stemming from preclinical data showing that sphinogosinephosphate S1P may play a role in the regulation of fibrosis, inflammation and choroidal neovascularization, a Phase I study was conducted investigating the tolerability of intravitreal injections of iSONEP, an anti-S1P monoclonal antibody. ARVO E-abstract Research efforts to enhance the understanding of the intricate relationship between visual function, blinking and dry eye were present in abundance across different groups of scientists and clinicians.

ARVO E-abstract Clinical research models and results of clinical trials of developing therapies were also presented. ARVO E-abstract In addition, a few intriguing examples of preclinical research with potential clinical application in the future emerged. ARVO E-abstract Finally, prior to ARVO, expert clinical researchers, scientists, regulators, pharmaceutical executives, and venture capitalists interested in dry eye convened at the Dry Eye Summit, an event co-sponsored by our pharmaceutical consulting firm, Ora. Ocular Infection In a preclinical study, the combination of dexamethasone and povidone-iodine 0.