Fingertips (Part 4)

As Wonder moves into his impromptu encore, the new bass player, Joe Swift, having replaced Larry Moses, can be heard on the recording, yelling out, "What key? The live version of "Fingertips" was released on May 21, as a two-part single, with Part 2 with the encore as the B-side.

The mono features "Sunset" and "Contract on Love".

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Postman " , and launched the then year-old Wonder into the pop music stratosphere. The single's success helped Wonder's live album, Recorded Live: The 12 Year Old Genius , reach number-one on the Billboard Pop Albums chart, making him the youngest artist to accomplish that feat. Because of Part 2's success, it would later feature on various compilation albums just as the full recording. Both the studio and live versions of the song featured drumming by Marvin Gaye , who had been playing drums for Wonder and other Motown artists in before becoming a famous hitmaker in his own right.

From Wikipedia, the free encyclopedia. This article is about the song by Stevie Wonder. For other uses, see Fingertips disambiguation. This section does not cite any sources. Please help improve this section by adding citations to reliable sources. Unsourced material may be challenged and removed. Precision and accuracy of this sign is not known.

Various hypotheses have been proposed over the years to explain the pathophysiology of digital clubbing. In patients with lung carcinoma and clubbing, Gosney et al. However, a subsequent study found no such relationship in patients with lung cancer. They suggest that these hormones may actually be cytokines, but its exact nature is not known. The most promising hypothesis in digital clubbing is that proposed by Dickinson and Martin in They noted dilated vessels, often containing platelets clusters within it in clubbed fingers. Other features of platelets activation e.

An experimental study in rats has shown no feature of clubbing on intermittent intravenous infusion of PDGF. Congenital nail clubbing is usually symmetrical and bilateral, but different fingers and toes may be involved to varying degrees. Some fingers or toes may be spared, but the thumbs are almost always involved. Chronically elevated prostaglandin E2 levels may be responsible for various clinical manifestations of clubbing.

PGE2 stimulates the activity of both osteoblasts and osteoclasts, thereby causing both bone deposition periostosis and resorption acro-osteolysis ,[ 99 ] the typical skeletal feature of PHO. Clubbed fingers can be differentiated from non-clubbed fingers by measurement of nail bed thickness, using plain radiograph. Pseudoclubbing PC is an atypical presentation of clubbing, characterized clinically by asymmetrical involvement of the fingers, and radiographically by resorption of the terminal tufts acro-osteolysis.

It has been described in chronic renal failure,[ ] subungal hemangioma,[ ] acrometastases,[ ] systemic sclerosis,[ ] etc. Exact mechanism is not known, but it could be the result of soft-tissue collapse due to distal phalangeal osteolysis. In PC, profile sign is usually normal and there is usually asymmetrical nails involvement.

Acro-osteolysis is classically present instead of soft tissue swelling of nail bed in clubbing. National Center for Biotechnology Information , U. Journal List Lung India v. Malay Sarkar , D. Mahesh , 1 and Irappa Madabhavi 2. Author information Copyright and License information Disclaimer.

INTRODUCTION

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3. This article has been cited by other articles in PMC. Abstract Digital clubbing is an ancient and important clinical signs in medicine. Cancer, digital clubbing, hypertrophic osteoarthropathy, megakaryocytes, vascular endothelial growth factor.

Table 1 Grading of clubbing. Open in a separate window. Table 2 Showing different conditions associated with clubbing. In acropachy, periosteal reaction can be asymmetric but in pulmonary osteoarthropathy, periosteal reaction usually is symmetric. In thyroid acropachy, radiographs show a characteristic subperiosteal spiculated, frothy, or lacy appearance, whereas in classic pulmonary osteoarthropathy, there is laminal periosteal proliferation.

Autoimmune phenomena, increased glycosaminoglycan and fibroblast proliferation explain the pathological changes of clubbing in thyroid acropachy[ 61 , 62 ]. Thyroid acropachy less commonly involve proximal long bones and periarticular areas, which occurs in rheumatoid arthritis and metabolic disorders including hyperthyroidism[ 57 ]. A vasoactive compound, endotoxin, or some other substance produced by bacteria adherent or adjacent to the graft.

Chronic infection of the arterial graft may also lead to formation of platelet clumps within vessels with secondary release of PDGF into the circulation leading to clubbing formation. Different signs of clubbing are the followings Profile sign or Lovibond's angle It was proposed by Lovibond[ 84 ] in the year and is also popularly known as Lovibond's angle. Hyponychial angle It is constructed by drawing a line from distal digital crease to the cuticle and another line from the cuticle to hyponychium which is the thickened stratum corneum of epidermis lying under the free edge of the nail.

Phalangeal depth ratio It is defined by the ratio of digit's depth measured at the junction between skin and nail nail bed and at the distal interphalangeal joint. Digital index It is the sum of phalangeal depth ratio for all 10 fingers. Schamroth sign This sign is named after Dr. Pathology of clubbed fingers Increased soft tissue in the fingertips of clubbed fingers. Increase width of nail-fold capillary[ ]. Footnotes Source of Support: Nil Conflict of Interest: Hanssen-flaschen J, Nordberg J.

Clubbing and hypertrophic osteoarthropathy. Loeb Classical Library, No. Exploring the cause of the most ancient clinical sign of medicine: Minor but important symptoms and signs in primary hypertrophic osteoarthropathy. Magnetic resonance imaging in pachydermoperiostosis. Possible association between deep infection and hypertrophic osteoarthropathy. Report of three cases and review of literature. Clinical, radiologic, and scintigraphic characteristics.

Two cases presenting as acute inflammatory arthritis. Description and review of the literature.

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Periostitis and hypertrophic pulmonary osteoarthropathy: Report of 2 cases and review of the literature. Michalakis K, Moutzouris DA. Hypertrophic osteoarthropathy and digital clubbing in lung adenocarcinoma. Paraneoplastic digital clubbing and hypertrophic osteoarthropathy. Altman RD, Tenenbaum J. WB Saunders Company; Hypertrophic osteoarthropathy in association with pulmonary metastases from extrathoracic malignancies.

Short Report Finger clubbing in malignant Mesothelioma and benign asbestos pleural disease. Unusual presentation of thymic carcinoma: Korean J Intern Med. Digital clubbing associated with pulmonary artery sarcoma. A case of finger clubbing associated with nasopharyngeal carcinoma in a young girl, and review of pathophysiology. J Pak Med Assoc. An unusual manifestation in nasopharyngeal cancer. Finger clubbing and a lung mass. Rhabdomyosarcoma associated hypertrophic osteoarthropathy in a child: Detection by bone scintigraphy.

Primary lymphosarcoma of lung associated with hypertrophic pulmonary osteoarthropathy. Reversible finger clubbing in a case of purgative abuse.

Fingertips - Wikipedia

Finger clubbing and aspartylglucosamine excretion in a laxative-abusing patient. An unusual side effect of interferon alfa 2A: J Ayub Med Coll Abbottabad. The prevalence of clubbing in different types of lung cancer. Hippocratic fingers and hypertrophic osteoarthropathy study of cases. Br J dis chest. Digital clubbing as the initial diagnosis of bronchogenic cancer. Prevalence of digital clubbing in bronchogenic carcinoma by a new digital index. Digital clubbing and lung cancer. Hirakata Y, Kitamura S. Eur J Clin Invest. The rational clinical examination. Does this patient have clubbing?

McGavin C, Hughes P. Short report finger clubbing in malignant mesothelioma and benign asbestos pleural disease. Solitary fibrous tumors of the pleura: Eight new cases and review of cases in the literature. Vandemergel X, Renneboog B. Prevalence, etiology and significance of clubbing in a Department of General Internal Medicine.

Euro J Internal Med.

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Hypertrophic Pulmonary osteoarthropathy in pulmonary metastases. Hypertrophic pulmonary osteoarthropathy in association with pulmonary metastases from extrathoracic tumours. Clubbing in association with pulmonary metastases from renal carcinoma-a case report. Hodgkin's lymphoma with digital clubbing. General principles and diagnostic approach to the interstitial lung diseases. Textbook of respiratory medicine. Clubbing of the fingers and smooth-muscle proliferation in fibrotic changes in the lung in patients with idiopathic pulmonary fibrosis.

Idiopathic pulmonary fibrosis in patients younger than 50 years. Hypertrophic pulmonary osteodystrophy in four patients with interstitial pulmonary disease. Significance of finger clubbing in asbestosis. Hippocratic digital and Crohn's disease. Finger clubbing in inflammatory bowel disease: Its prevalence and pathogenesis. Increased P-selectin CD62 expression on platelets from capillary whole blood of patients with Crohn's disease.



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The nail in systemic diseases. Hypertrophic osteoarthropathy in the hepatopulmonary syndrome. Medicine Baltimore ; Prospective study of periostitis and finger clubbing in primary biliary cirrhosis and other forms of chronic liver disease. Hypertrophic osteoarthropathy in portal cirrhosis. Hypertrophic osteoarthropathy in biliary atresia. Grekas D, Avdelidou A. Digital clubbing as an unusual complication associated with severe secondary hyperparathyroidism: Report of two cases. Report of 40 patients treated at a single institution in a year period.

J Clin Endocrinol Metab. Review of cases. Winkler A, Wilson D. Case report and literature review. Med Clin North Am. Stimulation of glycosaminoglycan accumulation by interferon -gamma in cultured human retroocular fibroblasts. Digital clubbing in HIV-infected patients: Digital clubbing in tuberculosis — relationship to HIV infection, extent of disease and hypoalbuminemia. Cutaneous manifestations of cardiovascular diseases. Hypertrophic osteoarthropathy in cyanotic congenital heart disease: Its prevalence and relationship to bypass of the lung.

Clubbing in African patients with pulmonary tuberculosis. Clubbing in pulmonary tuberculosis. The importance of finger clubbing in pulmonary tuberculosis. Prevalence and associated features of the cold hemiplegic arm. Unilateral clubbing of the fingers. With a Summary of the Literature. Unilateral clubbing of the fingernails in patients with hemiplegia.

Nail pathology in patients with hemiplegia.