Gene Therapy of Cancer: Translational Approaches from Preclinical Studies to Clinical Implementation
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The latter includes discussion of epitope-specific immunotherapies targeting mutated ras genes , genetic immunisation using dendritic cells loaded with tumour DNA or RNA or by the use of gold particles. Sections on immunotherapy include adoptive immunotherapeutic techniques, and genetic modification of haematopoietic stem cells. Specific therapies, such as oncogene or tumour suppressor gene targeting, antisense downregulation of apoptosis, anti-angiogenic gene therapy, manipulation of drug resistance genes in stem cells and clinical trial results using oncolytic viruses replication-selective viruses are also discussed.
One omission is a description of transcriptional targeting to provide specificity of delivery of the genes of interest, where promoter and enhancer elements of a gene expressed in a given tissue or tumour type are used to drive expression of the therapeutic genes.
When gene-directed enzyme prodrug therapy is to be used, transcriptional targeting can provide additional specificity to that obtained by injecting the organ of interest. Finally, the place of combined therapies, using gene therapy plus ionising radiation for treating cancer, is examined.
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Each chapter in the book is written by a world-renowned researcher s in the field and includes an excellent coverage of basic biology through to the use of very recent strategies, together with future perspectives. The book covers preclinical work through to clinical trials, pointing out the advantages and drawbacks that have been identified to date.
Gene Therapy of Cancer : Edmund C. Lattime :
The referencing is excellent and comprehensive. I strongly recommend this book to gene therapists, including virologists and molecular biologists determining vector structures, researchers performing preclinical studies, immunologists determining immunological strategies, oncologists conducting clinical trials and pathologists, as well as pharmaceutical companies. Be the first to know when a new issue is online. If you are a seller for this product, would you like to suggest updates through seller support? The Second Edition of Gene Therapy of Cancer provides crucial updates on the basic science and ongoing research in this field, examining the state of the art technology in gene therapy and its therapeutic applications to the treatment of cancer.
The clinical chapters are improved to include new areas of research and more successful trials. Chapters emphasize the scientific basis of gene therapy using immune, oncogene, antisense, pro-drug activating, and drug resistance gene targets, while other chapters discuss therapeutic approaches and clinical applications. This book is a valuable reference for anyone needing to stay abreast of the latest advances in gene therapy treatment for cancer.
Read more Read less. Here's how restrictions apply. An invaluable reference to this rapidly expanding field. Academic Press; 2 edition March 12, Language: Be the first to review this item Amazon Best Sellers Rank: Start reading Gene Therapy of Cancer on your Kindle in under a minute. Don't have a Kindle?
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