Molecular Biology

Molecular biology chiefly concerns itself with understanding the interactions between the various systems of a cell, including the interactions between DNA, RNA and protein biosynthesis, the transcription factor as well as learning how these interactions are regulated.

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It is obvious why open access and open data portals would be beneficial to the public: The diversity of information available in Open Access also makes it possible for Scholars and other information users to have wide access to more information. Molecular Biology an academic journal provides an opportunity to share the information among the medical scientists and researchers. Scholarly Open Access journal aims to publish most complete and reliable source of information on the discoveries and current developments in the mode of original articles, review articles, case reports, short communications, etc.

Open Access also maximizes the visibility of research publications and improves the quality, impact and influence of research globally. Molecular Biology Methods are common methods used in molecular biology , biochemistry , genetics and biophysics which generally involve manipulation and analysis of DNA , RNA , protein , and lipid.

The methods of molecular biology includes: Related Journal of Methods in Molecular Biology. Molecular Biology and Evolution is a journal that publishes research related to molecular and evolutionary biology.

Molecular biology

Apart from fundamental discoveries of broder scope and impact it also deals with the new and improved methods, resources, technologies and theories that assist in enhancing the evolutionary research. On the contraty Molecular evolution is a change in the sequence composition of cellular molecules such as DNA, RNA, and proteins across generations.

The field of molecular evolution uses principles of evolutionary biology and population genetics to explain patterns in these changes and publish balanced reviews of recent developments in genome evolution and future perspectives that suggests future dimensions in the field and application of molecular evolution.

Related Journal of Molecular Biology and Evolution. An open access peer-reviewed scientific journal that publishes research within systems biology at the molecular level including - genomics, proteomics , metabolomics , microbial systems at the molecular level, the integration of cell signaling, regulatory networks, and synthetic biology. The journal had a impact factor of Defines a process in which recombinant DNA molecules are produced and further transformed into a host organism, where they are replicated.

This process consists of two components: The DNA of interest like Operon is prepared for cloning by exercising it out of the source DNA using restriction enzymes and using PCR for copying it moreover assembling it from individual oligonucleotides. Application of molecular medicine to the clinics which are useful in treatment of infectious diseases. These methods have become increasingly important in clinical microbiology laboratory in detection and characterisation of virus infections.

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Molecular detection has mostly been introduced in the clinical microbiology labs in the form of PCR technology. On the contrary microarray technology such as the DNA chip will further increase the utility of molecular detection in the clinical microbiology labs. Its an approach to the field of computational molecular biology. It deals with the major issues concerning analysis of genomes, sequences and structures. This course introduces the basic computational methods used to understand the cell on a molecular level. It covers subjects such as the sequence alignment algorithms: Furthermore, it focuses on computational approaches to: Related Journals of Computational Molecular Biology.

Chip stands for Chromatin immunoprecipitation , a technique used to investigate interaction between proteins and DNA in the cell. The main aim is to determine whether specific proteins are associated with specific genomic regions like transcription factors on promoters or the DNA binding sites.

It also determines the specific location in the genome indicating the target of histone modifiers. There can be anywhere from spots to more than 10, on a given array. Arrays can also be made with molecules other than DNA. Allele-specific oligonucleotide ASO is a technique that allows detection of single base mutations without the need for PCR or gel electrophoresis. Short nucleotides in length , labeled probes are exposed to the non-fragmented target DNA, hybridization occurs with high specificity due to the short length of the probes and even a single base change will hinder hybridization.

The target DNA is then washed and the labeled probes that didn't hybridize are removed. The target DNA is then analyzed for the presence of the probe via radioactivity or fluorescence. In this experiment, as in most molecular biology techniques, a control must be used to ensure successful experimentation. In molecular biology, procedures and technologies are continually being developed and older technologies abandoned.

Introduction to molecular biology

For example, before the advent of DNA gel electrophoresis agarose or polyacrylamide , the size of DNA molecules was typically determined by rate sedimentation in sucrose gradients , a slow and labor-intensive technique requiring expensive instrumentation; prior to sucrose gradients, viscometry was used. Aside from their historical interest, it is often worth knowing about older technology, as it is occasionally useful to solve another new problem for which the newer technique is inappropriate.

While molecular biology was established in the s, the term was coined by Warren Weaver in Weaver was the director of Natural Sciences for the Rockefeller Foundation at the time and believed that biology was about to undergo a period of significant change given recent advances in fields such as X-ray crystallography. Clinical research and medical therapies arising from molecular biology are partly covered under gene therapy. The use of molecular biology or molecular cell biology approaches in medicine is now called molecular medicine.

Molecular biology also plays important role in understanding formations, actions, and regulations of various parts of cells which can be used to efficiently target new drugs , diagnosis disease, and understand the physiology of the cell.

Molecular Biology of HIV

From Wikipedia, the free encyclopedia. For the scientific journal, see Biochemical Genetics. For more extensive list on protein methods, see protein methods. For more extensive list on nucleic acid methods, see nucleic acid methods.

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History of molecular biology. Central dogma of molecular biology Genetic code Genome Molecular biology institutes Molecular engineering Molecular microbiology Molecular modeling Protein interaction prediction Protein structure prediction Proteome Bioinformatics Cell biology. Molecular Biology of the Cell, Sixth Edition. Molecular cell biology 4th ed. Retrieved 31 December Journal of Visualized Experiments Current Protocols in Immunology. RNA methods and protocols. Methods in Molecular Biology Clifton, N. Technique, Theory, and Trouble Shooting". North American Journal of Medical Sciences.

Hal 1 April Methods San Diego, Calif. H 1 June Types, Applications and their future. American Journal of Obstetrics and Gynecology. Learn More in these related Britannica articles: The advances of molecular biology have made possible the comparative study of proteins and the nucleic acids, DNA and RNA. DNA is the repository of hereditary evolutionary and developmental information. The relationship of proteins to DNA is so immediate that they closely….

At the level of molecular biology, for example, life is regarded as a manifestation of chemical and energy transformations that occur among the many chemical constituents that compose an organism. As a result of the development of increasingly powerful and precise laboratory instruments and techniques, it is possible to….

Technological advances in the identification of pathogenic agents.

New analytic methods in molecular biology have made genetic studies for the characterization and identification of bacteria more practical. The DNA hybridization technique is an example. Protein , highly complex substance that is present in all living organisms. Proteins are of great nutritional value and are directly involved in the chemical processes essential for life. More About Molecular biology 15 references found in Britannica articles Assorted References academic development In biology In biology: Biology in the 20th and 21st centuries identification of pathogenic agents In plant disease: Technological advances in the identification of pathogenic agents place in philosophy of biology In biology, philosophy of: Molecular biology disciplines biochemistry In biochemistry biophysics In biophysics evolution In evolution In evolution: Molecular biology In evolution: DNA and protein as informational macromolecules physiology In physiology: Intradisciplinary work View More.